| 01 |  Fede Vigevani@fedevigevani | YouTube | Entertainment | 81.1M |
| 02 |  YOLO AVENTURAS@yoloaventuras | YouTube | Entertainment | 71.3M |
| 03 |  Juan De Dios Pantoja@juandediospantojaa | YouTube | Entertainment | 56.8M |
| 04 |  Karla Bustillos@karlabustillos | YouTube | Entertainment | 53.8M |
| 05 |  Susy Mouriz@susymouriz | YouTube | Entertainment | 43M |
| 06 |  Liza Baez@lizabaez | YouTube | Entertainment | 32.2M |
| 07 |  Rubén Tuesta oficial@tuestaok | YouTube | Entertainment | 29.7M |
| 08 |  ChuuyMine@chuuymine | YouTube | Gaming | 24.6M |
| 09 |  MARIANA@marianamiamorch | YouTube | Entertainment | 20.9M |
| 10 |  José Totoy en Español@josetotoyespanol | YouTube | Entertainment | 18.1M |
| 11 |  Chingu amiga@chinguamiga | YouTube | Entertainment | 16.5M |
| 12 |  Netflix Latinoamérica@netflixlatam | YouTube | Entertainment | 14.4M |
| 13 |  Más SKabeche@masskabeche | YouTube | Entertainment | 14.4M |
| 14 |  ElAbrahaham@elabrahaham | YouTube | Entertainment | 14.1M |
| 15 |  TheHectorino@thehectorino | YouTube | Entertainment | 12.9M |
| 16 |  Silvio Gamer@silviogamer | YouTube | Gaming | 11.5M |
| 17 |  Meli Rico@melirico | YouTube | Entertainment | 11.3M |
| 18 |  Daniel Carreón@danielcarreon | YouTube | Education & Commentary | 10.4M |
| 19 |  Lizbeth Rodriguez@soylizbethrodriguez | YouTube | Entertainment | 10.3M |
| 20 |  ElMariana Gaming@elmarianajuega | YouTube | Gaming | 9.86M |
| 21 |  Bobicraft@bobicraftmc | YouTube | Gaming | 9.57M |
| 22 |  Rayito@debryanshow | YouTube | Entertainment | 8.95M |
| 23 |  MILENIO@milenio | YouTube | Education & Commentary | 8.32M |
| 24 |  Max y Noelia@maxynoelia1 | YouTube | Entertainment | 7.79M |
| 25 |  Browney en Español@browneyespanol | YouTube | Fitness & Health | 7.6M |
| 26 |  Chuy Mine@chuymine | YouTube | Gaming | 6.61M |
| 27 |  FedeGames@fedegames7 | YouTube | Gaming | 6.38M |
| 28 |  Andrea Zuñiga@andreazuniga | YouTube | Entertainment | 6.37M |
| 29 |  Andres Garza@andresgarzam | YouTube | Finance | 5.52M |
| 30 |  Coreano Vlogs@coreanovlogs | YouTube | Entertainment | 5.3M |
| 31 |  Kori@korioficial | YouTube | Gaming | 5.05M |
| 32 |  Chuy Almada@chuyalmada | YouTube | Fitness & Health | 4.81M |
| 33 |  Lupita Anaya@lupitaanaya | YouTube | Education & Commentary | 4.73M |
| 34 |  Dominguero@dominguero | YouTube | Travel | 4.02M |
| 35 |  Adrián Marcelo@adrianm10 | YouTube | Entertainment | 3.71M |
| 36 |  Mr Doctor@mrdoctor | YouTube | Entertainment | 3.6M |
| 37 |  Campechaneando@campechaneando | YouTube | Education & Commentary | 3.41M |
| 38 |  Apple México@applemexico | YouTube | Tech | 3.4M |
| 39 |  Conny Merlin@connymerlin | YouTube | Entertainment | 3.02M |
| 40 |  Aldara y Alex@aldarayalex | YouTube | Entertainment | 2.95M |
| 41 |  Penitencia@penitencia_mx | YouTube | Education & Commentary | 2.9M |
| 42 |  Alex PH@alexph | YouTube | Entertainment | 2.78M |
| 43 |  Exatlón México@exatlon | YouTube | Sports | 2.69M |
| 44 |  Speed Amigos@speedamigos | YouTube | Entertainment | 2.69M |
| 45 |  Gawx Art@gawxart | YouTube | Art & Design | 2.6M |
| 46 |  Nayo Escobar@nayoescobar | YouTube | Education & Commentary | 2.41M |
| 47 |  Brincos Dieras Oficial@brincosdierasoficial | YouTube | Entertainment | 2.36M |
| 48 |  Shark Tank México@sharktankmexico | YouTube | Entertainment | 2.29M |
| 49 |  UnderSide 821@underside_821 | YouTube | Music | 2.24M |
| 50 |  Pelicomic@pelicomic | YouTube | Entertainment | 2.15M |